Anthelmintic Drugs Raw Material API Powder For Dogs, Cats, Cattle, Pigeons Ivermectin

Anthelmintic Drugs Raw Material API Powder For Dogs, Cats, Cattle, Pigeons Ivermectin

Ivermectin is a kind of antibiotic medicine which has a driving and killing effect on nematodes, insects and mites. Ivermectin can also be available for the treatment of plant-parasitic nematodes(ascarid, lungworm) in poultry.

Send InquiryChat Now

Product Details

Anthelmintic Drugs Raw Material API Powder for Dogs, Cats, Cattle, Pigeons Ivermectin

Chemical & Physical Properties:

CAS NO: 70288-86-7

Molecular Formular: C48H74O14

MW: 875.09

EINECS: 274-536-0

HS Code: 29322090

Storage Temp.: 2-8°C

 

Pharmacologic Action

Ivermectin has killing effects on microfilaria, but its exact mechanism is not clear. It can be used as agonist for neurotransmitter γ-tyrosine(GABA) to break the transfer process of synapses in the central nervous system neurons mediated by GABA, which can lead to death of polypide by paralyzing its nervous system. As for adult insects, ivermectin doesn’t work, but it can affect the normal development of microfilariae of onchocerca volvulus in the female uterus, and can inhibit the release from the pregnant worm palace. Ivermectin has slow and persistent effect on microfilaria compared with diethylcarbamazine. It can quickly reduce the number of microfilariae of patients with the skin. However, it has a relatively slow effect on the larva of patients’ cornea and anterior chamber of eyes, therefore the number of larva in this area declines rather slow.


Pharmacokinetics

After taking the medicine orally, blood concentration will reach the peak in 4 hours and T1/2 in 10 hours. Animal experiments showed only l~2% of oral doses appears in the urine in the form of original drug and the others is excreted with excrement. The drug concentration in the liver and adipose is very high, but cannot penetrate the blood brain barrier, while in the nerve cells including GABA the concentration is rather low, hence we rarely see the response of central nervous system after taking medicine.


Usage and Dosage

Take the medicine orally one hour before the meal. The usual dose of onchocercosis treatment: 0.15-0.2mg/kg according to the weight, every 6-12 month at a time, depending on the symptoms and the reappear time of microfilaria. It can prevent the further development of ocular disorders(mostly caused by microfilaria), but this can’t be a radical treatment, because it’s inability to kill adult insects.


Untoward Effects

 Non-infected people and other Mammalian species are well tolerant towards this product. Symptoms like drowsiness, ataxia, mydriasis, tremble and even death will appear when given mega dose of this product to animals. The patients who suffer from onchocercosis may have transience and slight side effect after taking this medicine, most of which are rash and pruritus(caused by the death of microfilaria in the skin), lymphadenopathy(gall, seen in the neck, armpit, and inguen). It is rare to see the symptoms such as swirl, postural hypotension(faint), radiation, headache, joint sore, weakness and so on. There is not much change in ocular lesions. Occasionally, we can see the change of electrocardiogram but the significance is unclear. This product has no carcinogenic and teratogenic effect.

 

Package: 25 kg/drum

 


Hot Tags: anthelmintic drugs raw material api powder for dogs, cats, cattle, pigeons ivermectin, manufacturers, factory, price, discount, free sample

Previous: CAS 14769-73-4 Antiparasites Function Levamisole Hydrochloride, Levamisole HCL API Raw Material Powder Next: CAS 59-40-5 Bulk Powder For Sale Coccidiosis Treatment Poultry Sulfaquinoxaline For Cattle, Rabbits And Chickens

Related Products

Inquiry