The difference among Acetylisovaleryltylosin Tartrate, Timicosin, Tiamulin, and Tylosin

- Jan 11, 2018 -

What is the difference between Acetylisovaleryltylosin Tartrate and Tiamulin?


Acetylisovaleryltylosin Tartrate and tiamulin are completely different products. Tiamulin is not a macrolide antibiotic, is a diterpene drug what can only inhibit the growth and reproduction of Mycoplasma. But Acetylisovaleryltylosin Tartrate (also called Tylvalosin tartrate) can kill Mycoplasma. Acetylisovaleryltylosin Tartrate  mycoplasma minimum inhibitory concentration of Mycoplasma is wonderful one tenth of mycotoxin. Acetylisovaleryltylosin Tartrate also has the function of enhancing non-specific immunity and inhibiting the replication and growth of the human ear virus in macrophages, and is a more versatile antibiotic that is more suitable for the development of large-scale pig farms. The main function of Acetylisovaleryltylosin Tartrate is: kill mycoplasma directly, inhibit the replication of PRRSV, enhance non-specific immunity, promote growth, prevent and cure swine proliferative enteritis (ileitis), swine dysentery.


What is the difference between Acetylisovaleryltylosin Tartrate (Tylvalosin tartrate) and Tilmicosin?


Tylvalosin tartrate and Tilmicosin are the newest generation of macrolides, all of which inhibit the function of the PRRS virus. The difference is that Tylvalosin tartrate is a jointly validated function of laboratory and field trials; and Tilmicosin is only laboratory evidence of a slight inhibition of PRRSV , In actual operation have some difficulties. Tilmicosin in vitro to reach the same effect of Tylvalosin tartrate against PRRSV needs concentration of 10 times more than Tylvalosin tartrate, and Tilmicosinl in increasing dosage prone to poisoning deaths.


The effect of Tylvalosin tartrate against the blue-ear virus is even more pronounced than that of Tilmicosin, with lower concentrations of the required drugs and higher safety of the drug to pigs. Therefore, prevention and control of pigs for blue-ear disease should be given priority to use Tylvalosin tartrate.


What is the difference between Tylvalosin tartrate and Tylosin?


As a component derivative of tylosin, Tylvalosin tartrate is introduced into isovaleryl, which makes liposomally lipophilic and can accumulate in the cytoplasm through the cell membrane. The concentration of tylosin in pig intestinal epithelial cells, porcine kidney cells and porcine leukocytes was 8.5, 5 and 2 times higher than that of Tylvalosin tartrate; Tylosin basically did not enter the cells and had no antiviral activity . Second, the Tylvalosin tartrate toxin metabolites: 3-O-acetyl tylosin also has strong antibacterial activity. The tylosin metabolites do not have antibacterial activity. Although tylosin is a macrolide drug, its addition to Tylvalosin tartrate at a dose of 10-fold showed no inhibition of PRRSV.


What is the difference between tiamulin and tylosin?


Both are prophylactic and therapeutic agents for mycoplasma. However, bacteria are found to be susceptible to tylosin in practice.

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