The Application of Ivermectin

- Apr 02, 2018 -

Ivermectin is currently the most advanced anti-parasite drugs in the world. It has a strong killing effect on nematodes, insects and cockroaches. It is mainly used to exterminate the in vitro and in vivo parasites (such as gastrointestinal nematodes and lung filarial animals) and ectoparasites (such as cockroaches, cockroaches, cockroaches, cockroaches, and cockroaches) of animals such as pigs, cattle, and sheep.

 

Ivermectin is a semi-synthetic macrolide multicomponent antibiotic produced by the fermentation of Streptomyces avermitilis. 


Ivermectin is a white crystalline powder and tasteless. It is easily soluble in methanol, ethanol, acetone and ethyl acetate, and almost insoluble in water.

 

Ivermectin is also extremely effective against ticks and flies that reproduce in feces. Although ivermectin does not immediately cause death or dismemberment of fleas, it can affect foraging, molting, and spawning, thereby reducing fertility.

 

The pharmacokinetics of ivermectin are significantly different due to the inability of the species and route of administration. After the drug is absorbed, ivermectin is widely distributed in body tissues and has the highest concentration in the liver and adipose tissue. Ivermectin is usually oxidized to metabolites in the liver. More than 90% of fecal excretion occur in 5 to 6 days, and only 0.5% to 2% is excreted in urine.

 

Cattle, horses, sheep may be used in an amount typically 0.2mg / kg orally or subcutaneously.


In pigs, intramuscular injection of 0.3 mg/kg has a broad-spectrum anthelmintic activity against pigs. Good control of swine blood stasis and swine fever.


Dogs and cats, some countries have special dosage forms (by 6 to 12 micrograms/kg) for the prevention and treatment of canine heartworm microfilariae infection. In China someone try 50 micrograms/kilograms of oral administration for the treatment of heartworm microfilariae larvae (invalid adults). Clinical trials have confirmed that high doses of ivermectin are highly effective against a variety of parasites in dogs. Most varieties of dogs are safer to use ivermectin, but there is a long-haired shepherd dog sensitive to this product.


Poultry is highly effective when taken orally or subcutaneously in doses of 200-300 μg/kg.

 

 

 

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