The application of Diclofenac

- Apr 10, 2018 -

In the 1990s, scientists discovered that vultures are suffering from kidney failure because of the anti-inflammatory veterinary drug known as diclofenac in carrion eaten by vultures. Because of cultural beliefs, few people eat beef. Farmers will leave the dead cows directly in the fields. When the vultures became ill after eating, the number of deaths soared.


Diclofenac is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects. The mechanism of action of diclofenac is to selectively cleave the action of cyclooxygenase in the arachidonic acid metabolism series and block the synthesis pathway of prostaglandin E2 (PGE2). Diclofenac repressor mutagenic effect induced pain.Diclofenac is a phenylacetic acid anti-inflammatory analgesic with significant anti-rheumatic, anti-inflammatory, analgesic and antipyretic effects. Diclofenac is 2 to 2.5 times stronger than indometacin and 26 to 50 times stronger than aspirin.


In 2003, researchers found that the sudden and large-scale disappearance of the three most common bald eagles in India may be related to diclofenac. The reduction of vultures has led to an increase in the number of wild dogs, and more and more wild dogs have also increased the risk of rabies in humans. Not only that, the growth of the wild dog population in the villages and the wilderness led to the leopards living in the deep forest instead of hunting wild dogs, which increased the chance of the leopards hurting people. At the same time, because wild dogs use less efficient decomposition of carrion than vultures (its strong acid properties inhibit bacterial growth), it further exacerbates the deterioration of the natural environment.


Diclofenac causes uric acid crystals to accumulate in organs (especially the kidneys), and kidney failure leads to bird death. Subsequently, India, Nepal, Pakistan, and Bangladesh stipulated that the use of the drug in animals is prohibited. Africa is also trying to ban the use of the drug. The SAVE project is trying to push the EU to issue a ban on the drug.


If diclofenac is used properly, the anti-inflammatory effect on animals is very good.


If you want to know more information about diclofenac, please inquiry us.


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