Pharmacological Mechanism of Metronidazole

- Mar 29, 2018 -

1. Metronidazole can inhibit the synthesis of bacterial DNA, thus metronidazole interferes with the growth and reproduction of bacteria and eventually causes bacterial death. Metronidazole can kill the cells and anaerobic microorganisms in the condition of hypoxia, and the metabolites produced in the reduction of the human body also have the function of resisting anaerobic bacteria, and their sterilization concentration is slightly higher than that of bacteriostatic concentration.


2. The redox reaction of the amoeba can be inhibited so that the nitrogen chain of the original worm is broken;


3. Metronidazole also has a strong role in killing Trichomonas. Metronidazole has a strong antibacterial effect on most anaerobic bacteria, but it has no effect on aerobic and anaerobic bacteria.


In addition, metronidazole plays a strong role on Trichomonas, amoeba, Guinea worm and other microorganisms. The antimicrobial spectra of metronidazole include the vulnerable and other bacillus, Clostridium difficile, the Clostridium difficile, the real bacilli, the Vejon cocci, the digestive cocci and the digestive streptococcus. The genus Actinomyces, Lactobacillus, and propionic acid were resistant to metronidazole.




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