- Jan 15, 2018 -
Indoxacarb is an oxadiazine pesticide developed by DuPont that acts against lepidopteran larvae. It is marketed under the names Indoxacarb Technical Insecticide, Steward Insecticide and Avaunt Insecticide. It is also used as the active ingredient in Syngenta line of commercial pesticides: Advion and Arilon.
Its main mode of action is via blocking of nerve sodium channels. It is fairly lipophilic with a Kow of 4.65. This pesticide should be used with caution since some insects like Helicoverpa assulta become even more resistant when expose.
Indoxacarb is the active ingredient in a number of household insecticides, including cockroach and ant baits, and can remain active after digestion.  In 2012 DuPont's Professional Products including the line of Advion and Arilon products was purchased by Syngenta. Indoxacarb is the active ingredient in the new pet product, Activyl from Merck Animal Health. It is marketed to kill fleas on dogs and cats.
3.Mechanism of action of Indoxacarb
Indoxacarb has a specific mode of action. It blocks the movements of sodium ions in certain nerve cells, which results in paralysis and death of the affected insects.
It has been shown that this mechanism is different from the one of other pesticides that also act on sodium transport in nerve cells
4.Indoxacarb Side Effects, Adverse Drug Reactions (ADRs) and Warnings
In some cats transient salivation (drooling), licking of the face and shaking of the head has been reported.
A possible administration error in dogs is partial administration to small dogs of spot-ons approved for large dogs.
A possible administration error in cats is partial administration to cats of spot-ons approved only for dogs.
Never use spot-ons for dogs on cats; never use spot-ons for large dogs on small dogs. It happens that some users want to save money buying large spot-ons for treating smaller dogs (or even cats!) twice or more times. The risk of overdosing is considerable, either due to erroneous calculations or to unskilled manipulation. In addition, dog medicines may sometimes contain other ingredients that are toxic to cats.
5.Antidote and Treatment of Indoxacarb Intoxication
There is no antidote for indoxacarb poisoning.
Treatment consists in preventing further exposure together with supportive and symptomatic measures.
To reduce exposure after spot-on treatment wash affected animals thoroughly with abundant lukewarm water and soap to remove the chemicals from the animal's hair coat.
6.Pharmacokinetics of Indoxacarb
After topical administration, indoxacarb remains mainly on the hair coat and skin of the treated pets. A small amount is also ingested through licking and/or grooming (particularly in cats).
Absorbed indoxacarb is extensively metabolized (>90%) in the liver to inactive metabolites. Excretion is mainly through the feces.
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