Detailed Introduction about Ivermectin

- Sep 20, 2018 -

The dihydrogen derivative of ivermectin avermectin B has been widely used in nematodes, mites, mites, mites, maggots and other in vitro and in vivo parasitic diseases in animals such as pigs, cattle, sheep, horses, rabbits and poultry. It has a killing effect on a variety of parasites, and is recognized as a new class of antiparasitic drugs with broad spectrum, high efficiency, safety, little residue and no drug resistance.


Insects such as nematodes and arthropods have a neurotransmitter system with gamma-aminobutyric acid (GABA) as a transmitter. GABA function is to transmit inhibitory nerve signals and plays an important role in regulating nerve function. The effect of ivermectin on nematodes is to block the conduction between interneurons and motor neurons in the nervous system of the worm. This blockade is achieved by potentiating the action of GABA, which increases the release of GABA in the target animal and enhances the ability of GABA to bind to receptors on postsynaptic cells.


Thereby, the normal resting position energy on the post-synaptic cell membrane is improved, and it is difficult for the nerve to transmit the stimulation to the muscle, so that the muscle cells can not contract, and the worm body is rashly paralyzed and died. This effect of ivermectin can in turn be reversed by the GABA antagonist bitter taste (Cl-tube blocker).


Ivermectin is the most common insecticidal application to arthropods. It has a good effect on cockroaches, pruritus, blood stasis and avian knees in cattle and sheep. For livestock that are affected by cockroaches, ivermectin does not immediately cause death and loss of cockroaches, but it can prevent life activities such as blood sucking, molting and reproduction, and it has different effects on different cockroaches. The effect of colorless burdock is obvious, and the cockroach can be completely controlled for 21 days to prevent its invasion, but it is not sensitive to certain cockroaches, such as deafness, and commonly used doses of ivermectin. Since the antiparasitic effect of ivermectin is carried out by GABA transmitters, and there are no GABA transmitters as nerve impulses in the worms and actinomycetes such as flat animals, bacteria and actinomycetes, ivermectin against trematode , aphids, bacteria, actinomycetes, etc. have no active effect.


Ivermectin has a strong deworming effect on nematodes and ectoparasites and other arthropods, but has little or no effect on trematode and aphids.


In order to make the insect-resistant spectrum wider, experts have proposed that a drug such as albendazole (albendazole), which is better than trematode and aphid, and ivermectin can be made into a mixture through a certain pharmaceutical process to make it resistant to insects. It is broader and more efficient, alleviating the hassle of multiple administrations for the simultaneous elimination of various parasites.

 

 

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