Application of Sulfonamide drugs

- May 19, 2018 -

Sulfa drugs are widely used in the clinical practice of swine disease due to its broad spectrum of antibacterial properties, ease of use, stability, and low price. However, improper use may lead to anaphylaxis of pigs, may also cause adverse reactions such as hemoglobinuria, anemia, and even endanger human health. Therefore, they should abide by six principles when applying sulfa drugs in the process of raising pigs.


Double the amount for the first time. The first use of sulfa drugs can achieve the purpose of rapid antibacterial doubling for the first time, and then use the normal amount until the symptom disappears to give a minimum of 2 or 3 times, in order to maintain a longer period of efficacy, to prevent bacterial rebound.


Pay attention to incompatibility. Sulfa drugs, especially compound synergistic sulfonamides, cannot be used alone with penicillin, sodium bicarbonate, calcium chloride, vitamin C, vitamin B, and compound sodium chloride solutions.


Do not use it for long periods of time. Although sulfa drugs have a good effect on bacteria such as Streptococcus suis, they are resistant to drug resistance. Once drug resistance occurs, all sulfa drugs will invalid, and other antibiotics should be quickly replaced. .


Ensure adequate drinking water. Drinking more water can maintain high urine flow and prevent drug crystallization. uses sulfa drugs for more than one week. If necessary, the pig can take sodium bicarbonate to basify the urine.


Vitamin B family. Sulfa drugs can inhibit the synthesis of vitamins B in the intestine. Therefore, when using sulfa drugs for more than one week, they should be given vitamin B family or more feeds to prevent their lack.


Must be stopped on time. In order to ensure the quality and safety of animal products, according to the provisions of national standards and professional standards for veterinary drugs, pigs should be discontinued on time before slaughter.

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