- Mar 20, 2018 -
1 : Product and Company Identification
Product Name: Amitraz
Molecular Formula: C19H23N3
Molecular Weight: 293.4
Chemical Name: N-methyl bis(2,4-xylylininomethyl) amine
Color: Clear yellowish
Odor: Characteristic petroleum odor
CAS No.: 33089-61-1
PANPAN INDUSTRY CO., LIMITED
Add: Room 308, Building No. 9, National University Science Park, Zhengzhou, China
2. Composition / Information on Ingredients
3. Hazards Identification
Tech: Fish: LC50 0.74 ppm (rainbow trout): 0.5 ppm (bluegill). Bee: Nontoxic. Bird: Oral LD50 788 mg/kg (bobwhite). Dietary: 7000 ppm (mallard).
4. First Aid Measures
Eyebaths or eyewash stations and safety deluge showers should be provided where this product is being used. If poisoning occurs, contact a Doctor or Poisons Information Centre. If possible have this MSDS or product label with you.
Swallowed: If swallowed, do not induce vomiting. Wash mouth with water and give a glass of water to drink. Seek medical attention.
Eyes: If this product comes into contact with eyes, hold open and wash with running water for at least 15 minutes. Ensure irrigation under eyelids by occasionally lifting them. Do not try to remove contact lenses unless trained. Seek medical attention.
Skin: If product gets on skin, immediately remove contaminated clothing and wash skin thoroughly with soap and water to remove material. If you begin to feel unwell, or if irritation persists, seek medical attention.
Inhalation: If vapors or mists have been inhaled, and irritation or unusual symptoms have developed, remove to fresh air and observe until recovered. If irritation or symptoms persists more than about 30 minutes, seek medical advice.
Advice to Doctor: Treat symptomatically. Note the nature of this product.
5. Fire-Fighting Measures
When fighting fires involving significant quantities of this product, wear safety boots, non-flammable overalls, gloves, hat, goggles and respirator. All skin areas should be covered.
6. Accidental Release Measures
Personal cautions: safety glasses or goggles, rubber gloves, shoes plus socks, long-sleeved shirt, and long pants and hats.
EX: clear the material in time. Transfer to a properly labeled deposit that will be closed and sealed until the recovery of elimination of the product. Environmental cautions
EX: prevent the contamination of the floor and of beds of water.
7. Handling and Storage
Do not store at temperatures below 0℃. Do not get in eyes, on skin, or clothing. Do not breathe mist, keep container closed. Wash thoroughly after handling. Do not contaminate food or feed products.
8. Exposure Controls/Personal Protection
Tightly woven long-sleeve shirt and long pants, rubber gloves, boots, face shield. Wear clean clothing each day, launder before reusing. Remove contaminated clothing immediately. Wash eyes with water. Wash other affected parts of body with soap and water. If the extent of contamination is unknown, bathe body thoroughly, change clothing.
9. Physical and Chemical Properties
Melting point: 86 - 87℃
Boiling point and vapor pressure: Not available.
PH value: 9.0 - 10.5
Volatile materials: No specific data. Expected to be low at 100℃.
Flashing point: 64℃
Flammability limits: Not applicable. This product is not flammable.
Specific gravity: 1.128 at 20℃
Water Solubility: ca. 1 mg/l (211). Soluble in common organic solvents including acetone, toluene, and xylene
Solubility in Other Solvents: Not Available
Vapor Pressure: 0.051 mPa at 20 ℃
Partition Coefficient: (octanol/water) Kow = 316,000
10. Stability and Reactivity
Stability: Slightly souble in water. Soluble in common organic solvents. Reactivity: Unlikely to spontaneously decompose.
11. Toxicological Information
Acute oral LD50 to rats is 500-600mg/kg, acute dermal LD50 to rabbitsis more than 0200 mg/kg. It is not irritant to eyes and skins of experimental animals
Teratogenic Effects: In one study, rats treated with 12 mg/kg/day of amitraz from days 8 to 20 of pregnancy, the offspring were heavier but had less bone development than the offspring of untreated rats. However, an EPA study indicates that the highest dose at 4 which amitraz has no observable effect on test rats' offspring (teratogenic NOEL) is 12 mg/kg/day. The teratogenic NOEL of rabbits is 25 mg/kg/day. These studies indicate that high doses of amitraz exposure during pregnancy produced adverse effects in laboratory animals. Likely human exposures are very much less than those which produced effects, and these effects are unlikely in humans under normal circumstances.
Mutagenic Effects: A variety of tests indicate that amitraz is not mutagenic and does not cause damage to DNA.
Carcinogenic Effects: Long term feeding studies show that amitraz is not carcinogenic in rats. However, it can cause tumors in female mice. Amitraz causes an increase in tumors of the lungs and lymph nodes in female mice, but not males, at 57 mg/kg/day over 20 months. A two-year study of female mice also showed an increase in tumors of the liver (hepatocellular tumors) at 57 mg/kg/day of amitraz. Because amitraz causes cancer in female mice, but not male mice or male or female rats, it is unclassifiable as to human carcinogenicity.
Organ Toxicity: At high doses, amitraz can reduce the function of the hypothalamus, which helps regulate the metabolism by controlling hormone release in the body. A daily dose of 200 mg of amitraz per kilogram of body weight for ten weeks causes decreased growth and food consumption.
12. Ecological and Ecotoxicological Information
Effects on Birds: Amitraz is slightly toxic to birds. The dietary LC50 (8 day) is 7,000 mg/kg for mallard ducks and 1,800 mg/kg for Japanese quail . The oral LD50 for bobwhite quail is 788 mg/kg . Amitraz may affect reproduction in birds. The avian reproductionNOEL is less than 40 ppm.
Effects on Aquatic Organisms: Amitraz is moderately toxic to fish. The LC50 (96-hour exposure) is 1.3 mg/l for bluegill sunfish and 3.2-4.2 mg/l for harlequin fish. For a 48-hour exposure of rainbow trout, a cold water species, the LC50 is 2.7-4.0 mg/l. Daphnia, a fresh water invertebrate, exhibited toxic effects at 35 ppb of amitraz in water.
Effects on Other Animals (Nontarget species): Amitraz is relatively non-toxic to bees. The LD50 is 12 micrograms per bee by ingestion and 3.6 mg/l by direct spraying.
13. Disposal Considerations
Spillage disposal: Do not wash away into sewer. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place
14. Transport Information
15. Regulatory Information